Journal
ARQUIVOS DE NEURO-PSIQUIATRIA
Volume 65, Issue 2B, Pages 433-439Publisher
ASSOC ARQUIVOS NEURO- PSIQUIATRIA
DOI: 10.1590/S0004-282X2007000300013
Keywords
juvenile systemic lupus erythematosus; neuropsychiatric syndromes
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Objective: To characterize neurological involvement in juvenile systemic lupus erythematosus. Method: The charts of all patients with the diagnosis of systemic lupus erythematosus before the age of 16 years, followed at the Rheumatology Unit of Pequeno Principe Hospital, from January 1992 to January 2006, were retrospectively reviewed, highlighting neuropsychiatric aspects, Results: Forty-seven patients were included. Neuropsychiatric syndromes were found 29 (61.7%): seizures (17/36.2%), intractable headache (7/14.9%), mood disorders (5/10.6%), cerebrovascular disease (4/8.5%), acute confusional state (3/6.4%), aseptic meningitis (3/6.4%), psychosis (3/6.4%), chorea (3/6.4%), Guillain-Barre syndrome (2/4.3%) and cranial neuropathy (1/2.1%). Morbidity indexes (SLEDAI and SLICC) were higher among patients with neuropsychiatric manifestations (p < 0.05). Conclusion: Neuropsychiatric syndromes are frequent, and add significant morbidity to juvenile systemic lupus erythematosus.
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