Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 349, Issue 8-9, Pages 1379-1386Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.200700051
Keywords
aldol reaction; amino alcohols; biocatalysis; lyases; threonine aldolase; tyrosine decarboxylase
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Funding
- Austrian Science Fund (FWF) [W 901] Funding Source: researchfish
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The applicability of the recent published bienzymatic protocol for the synthesis of (R)-2amino-1 -phenylethanol was tested using L-threonine aldolase from Pseudomonas putida and L-tyrosine decarboxylase from either Enterococcus faecalis (Efa) or two genes from Enterococcus faecium (Efi1, Efi2). In all 21 benzaldehyde derivatives were applied for an initial TLC screening. On a small scale, octopamine and noradrenaline were obtained as (S)-enantiomers using Efi1. Three protocols were up-scaled yielding enantioenriched (S)-octopamine (yield 99%, ee 81%), (R)-2-amino-1-phenylethanol (yield 61%, ee 62%) and (S)-noradrenaline (yield 76 %, ee 79 %).
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