Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1151, Issue 1-2, Pages 6-13Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chroma.2007.01.143
Keywords
CCC; CPC; dynamic extraction; countercurrent chromatography; industrial scale-up
Funding
- Biotechnology and Biological Sciences Research Council [BB/D524583/1] Funding Source: Medline
- Biotechnology and Biological Sciences Research Council [BB/D524583/1] Funding Source: researchfish
- BBSRC [BB/D524583/1] Funding Source: UKRI
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The pharmaceutical industries are looking for rapid methods of purification and predictable scale-up for their drug development process that will cut their costs and enable them to reduce the time to market. In this paper, recent progress is reviewed in the development and demonstration of two types of industrial scale centrifugal liquid-liquid chromatography: hydrostatic and hydrodynamic. Industrial scale hydrostatic processes by Partus Technologies and Armen Instrument are just emerging. Results demonstrating scalability are presented for hydrodynamic processes by Dynamic Extractions. The review concludes that the time is now right, with this appropriate commercial support, for high performance counter-current chromatography to emerge as a major enabling technology for industry. (C) 2007 Elsevier B.V. All rights reserved.
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