Journal
TETRAHEDRON LETTERS
Volume 48, Issue 23, Pages 4079-4082Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2007.04.008
Keywords
multicomponent reaction; imidazo[1,2-a]pyridines; zinc chloride; montmorillonite K10
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The novel use of zinc chloride to catalyze the one-pot, three component synthesis of imidazo[1,2-alpha]pyridines from a range of substrates using either conventional heating or microwave irradiation is described. This methodology affords a number of imidazo[1,2-alpha]pyridines in reasonable yields and short reaction times without any significant optimization of the reaction conditions. (c) 2007 Elsevier Ltd. All rights reserved.
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