Journal
ANALYTICAL CHEMISTRY
Volume 90, Issue 20, Pages 11775-11779Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.8b03807
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Funding
- National Natural Science Foundation of China [21673223, 21431007, 21533008, 21871249, 21820102009]
- Key Program of Frontier of Sciences [CAS QYZDJ-SSW-SLH052]
- Youth Innovation Promotion Association CAS [2014202]
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Nanozymes have been widely used for the construction of colorimetric sensors. However, the simultaneous discrimination of multiple targets using nanozymes is still a challenge. In this work, we construct a multiple-readout system for pattern recognition of proteins using nanozyme. Graphitic carbon nitride (g-C3N4) nanosheets, which possess peroxidase-like activity, are chosen as the single sensing receptor. The catalytic activity of g-C3N4 can be changed to different degrees owing to the different interactions between g-C3N4 and proteins. By choosing different combinations of absorbance intensities at various time points, multichannel information can be extracted from a single material for pattern recognition. The platform avoids the synthesis of multiplex sensing receptors and the requirement of sophisticated instruments, leading to lower cost and time consumption. The study provides a new method for the construction of feasible, convenient, and flexibly nanozyme-based sensing arrays.
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