Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 337, Issue 1-2, Pages 346-356Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2007.01.031
Keywords
cardiotoxicity; doxorubicin; human serum albumin; nanoparticles; poly(butyl cyanoacrylate); polysorbate 80; rat; testicular toxicity
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A toxicological study of doxorubicin bound to poly(butyl cyanoacrylate) or human serum albumin nanoparticles coated with polysorbate 80 was performed in healthy rats. The doxorubicin formulations were injected at a therapeutic dose regimen (3 x 1.5 mg/kg with a 72 h interval), and the animals were followed up for 15 or 30 days. The overall result of this study suggests that the surfactant-coated nanoparticle formulations of doxorubicin have favorable toxicological profiles. Specifically, these formulations display a considerably reduced cardio- and testicular toxicity, as compared to a free drug. (c) 2007 Elsevier B.V. All rights reserved..
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