Inductive Coupling and Flow for Increased NMR Sensitivity

A device is proposed to enhance the NMR sensitivity of slowly relaxing nuclei, taking advantage of a controlled solution flow within a microfluidic circuit and microsized NMR detection. Unlike our previous work (Carret et al. Anal. Chem. 2017, 89 (5), 2995-3000), this setup can be easily installed on any commercial NMR probehead as it uses induction between the commercial antenna and the microcoil. Such a system leads to a significant gain in sensitivity per time unit for slowly relaxing nuclei while preserving the capabilities of the host probehead.