4.8 Article

Highly enantioselective oxidation of sulfides to sulfoxides by a new oxaziridinium salt

Journal

ORGANIC LETTERS
Volume 9, Issue 12, Pages 2265-2268

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol0702573

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The new oxaziridinium salt 5 (R-2 = TBDPS) is an effective reagent for the highly enantioselective oxidation of sulfides to sulfoxides with up to > 99% ee and good yields. As such, it represents a new valuable nonmetallic alternative to the existing methods for asymmetric sulfoxidation.

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