Reconfigurable four-component molecular switch based on pH-controlled guest swapping

The four-component ensemble comprising CB[6], beta-CD, and guests 1 and 2 forms complexes CB[6]center dot 1H(+) and beta-CD center dot 2 at pH < 7 but swaps partners forming complexes CB[6]center dot 2 and beta-CD center dot 1 at pH > 13. The intermolecular nature of the switching process suggests application as a basis for stimuli-responsive reconfigurable systems.