Journal
TETRAHEDRON LETTERS
Volume 48, Issue 24, Pages 4271-4274Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2007.04.049
Keywords
alpha-chymotrypsin; ionic liquid; peptide synthesis
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alpha-Chymotrypsin catalyzed peptide bond formation was studied in ionic liquids using the synthesis of a protected fragment of Leu-enkephalin, ZTyrGlyGlyOEt, as model reaction. MOEMIM center dot PF6 was found to be the most favorable solvent among the six different 1-alkyl-3-methylimidazolium hexafluorophosphates and tetrafluoroborates ionic liquids screened. With MOEMIM-PF6 as reaction media, several di- or tripeptide derivatives were successfully prepared in 68-75% isolated yields. (c) 2007 Elsevier Ltd. All rights reserved.
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