Journal
TETRAHEDRON LETTERS
Volume 48, Issue 24, Pages 4281-4285Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2007.04.037
Keywords
asymmetric catalysis; organocatalysis; direct aldol reaction; NOBIN; water
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A rationally designed organocatalyst for direct asymmetric aldol reaction in the presence of water has been developed. High yield (up to 99%), diastereoselectivity (up to 99:1) and enantioselectivity (up to 97%) were obtained under optimal conditions. (c) 2007 Elsevier Ltd. All rights reserved.
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