Journal
ANALYTICAL CHEMISTRY
Volume 86, Issue 15, Pages 7987-7995Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ac502103t
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Funding
- National Natural Science Foundation of China [21105105, 21321003, 21135006, 21190032]
- Ministry of Science and Technology of China
- Chinese Academy of Sciences
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A new red-emissive bioprobe TPE-red-2AP2H was developed by taking advantage of the unique emission feature of tetraphenylethylene and a cancer cell-specific peptide. By responding to the target protein and the acidic micro-environment of tumor cells, activated fluorescence bioimaging was achieved with high signal-to-noise ratio and without involving mutiple washing steps. Apart from targeting the membrane-anchored LAPTM4B proteins, TPE-red-2AP2H was successfully utilized to trace the intracellular movement of LAPTM4B protein. The generation of 102 under visible light irradiation makes this bioprobe also promising for targeted-photodynamic therapy. By discriminating the expression level of the target protein, TPE-red-2AP2H can respond to the progression status of tumors with different photodynamic therapy effect.
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