Journal
FEBS LETTERS
Volume 581, Issue 14, Pages 2633-2640Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2007.05.006
Keywords
Jumonji; zfp496; transcription; heart; development
Funding
- NHLBI NIH HHS [HL67050, R01 HL067050-03, R01 HL067050-05A1, R01 HL067050, R01 HL067050-02, R01 HL067050-04, R01 HL067050-01A1] Funding Source: Medline
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Jumonij (JMJ)/Jarid2 plays important roles in embryonic development and functions as a transcriptional repressor. Using yeast two-hybrid screening, we have identified a cofactor of JMJ, the zinc finger protein 496 (Zfp496) that contains a SCAN, KRAB and zinc finger domain. Our molecular analyses indicate that Zfp496 functions as a transcriptional activator. Further, Zfp496 inhibits the transcriptional repression of JMJ and JMJ represses the transcriptional activation of Zfp496. This study demonstrates that JMJ physically and functionally interacts with Zfp496, which will provide important insights into endogenous target gene regulation by both factors. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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