Journal
FEBS LETTERS
Volume 581, Issue 14, Pages 2587-2592Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2007.05.023
Keywords
lysozyme; molten globule; calcium-binding; amyloid; oligomers; cytotoxicity
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Calcium-binding equine lysozyme (EL) combines the structural and folding properties of c-type lysozymes and alpha-lactalbumins, connecting these two most studied subfamilies. The structural insight into its native and partially folded states is particularly illuminating in revealing the general principles of protein folding, amyloid formation and its inhibition. Among lysozymes EL forms one of the most stable molten globules and shows the most uncooperative refolding kinetics. Its partially-folded states serve as precursors for calcium-dependent self-assembly, into ring-shaped and linear amyloids. The innate amyloid cytotoxicity of the ubiquitous lysozyme highlights the universality of this phenomenon and necessitates stringent measures for its prevention. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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