Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 129, Issue 23, Pages 7242-+Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja0715896
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- NIGMS NIH HHS [R01 GM069445] Funding Source: Medline
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The first highly enantioselective catalytic vinylation of aldimines to furnish allylic amines is reported. Exposure of aromatic and aliphatic N-arylsulfonyl aldimines 1a-12a to equal volumes of acetylene and hydrogen gas at 45 degrees C and ambient pressure in the presence of chirally modified cationic rhodium catalysts provides the (Z)-dienyl allylic amines 1b-12b in highly optically enriched form (93-98% ee) and as single geometrical isomers (>95:5, Z/E). The coupling products 1b-12b arise via multicomponent coupling of four molecules: two molecules of acetylene, a molecule of aldimine, and elemental hydrogen. Unlike other imine additions involving nonstabilized carbanions, the present protocol circumvents use of preformed organometallic reagents.
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