Journal
NEUROSCIENCE LETTERS
Volume 420, Issue 2, Pages 97-99Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2007.02.090
Keywords
Alzheimer's disease; mild cognitive impairment; retina; optical coherence tomography
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In Alzheimer's disease (AD), brain lesions are marked by severe neuronal loss and retinal degeneration was previously mentioned in affected patients. Mild cognitive impairment (MCI) is a clinical syndrome that could be an early phase of AD. In this study, using optical coherence tomography (OCT), the retinal nerve fiber layer (RNFL) thickness was assessed in patients with mild AD, moderate to severe AD, amnestic MCI and control subjects. The results show that RNFL thickness is statistically reduced in patients with MCI, mild AD or moderate to severe AD compared to controls. In addition, no statistical difference was found between the results in MCI patients and mild AD patients. The RNFL seems to be involved early during the course of aninestic MCI and OCT tests could be carried out in patients with cognitive troubles. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
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