Journal
BMC DEVELOPMENTAL BIOLOGY
Volume 7, Issue -, Pages -Publisher
BMC
DOI: 10.1186/1471-213X-7-67
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Funding
- Intramural NIH HHS Funding Source: Medline
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Background: Ovarian folliculogenesis in mammals is a complex process involving interactions between germ and somatic cells. Carefully orchestrated expression of transcription factors, cell adhesion molecules and growth factors are required for success. We have identified a germ- cell specific, basic helix- loop- helix transcription factor, FIGLA ( Factor In the GermLine, Alpha) and demonstrated its involvement in two independent developmental processes: formation of the primordial follicle and coordinate expression of zona pellucida genes. Results: Taking advantage of Figla null mouse lines, we have used a combined approach of microarray and Serial Analysis of Gene Expression ( SAGE) to identify potential downstream target genes. Using high stringent cutoffs, we find that FIGLA functions as a key regulatory molecule in coordinating expression of the NALP family of genes, genes of known oocyte- specific expression and a set of functionally un- annotated genes. FIGLA also inhibits expression of male germ cell specific genes that might otherwise disrupt normal oogenesis. Conclusion: These data implicate FIGLA as a central regulator of oocyte- specific genes that play roles in folliculogenesis, fertilization and early development.
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