Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 17, Issue 12, Pages 3339-3343Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2007.03.106
Keywords
CXCR3; IP10; ITAC; MIG; chemokine receptor
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A series of quinazolinone-derived inhibitors of the CXCR3 receptor have been synthesized and their affinity for the receptor evaluated. Compounds were evaluated in a I-125-IP10 displacement assay and in in vitro cell migration assays to I P 10, ITAC, and MIG using human peripheral blood mononuclear cells. (c) 2007 Elsevier Ltd. All rights reserved.
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