Journal
JOURNAL OF THE NEUROLOGICAL SCIENCES
Volume 257, Issue 1-2, Pages 166-173Publisher
ELSEVIER
DOI: 10.1016/j.jns.2007.01.026
Keywords
hypertension; age-related white matter changes; cognitive function; gait; disability
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Brain microangiopathy, whose neuroimaging expression is represented by age-related white matter changes (ARWMC), is largely due to hypertension and it is, in turn, responsible for geriatric syndromes, including decline in cognitive, functional and motor/gait abilities. This review analyzes the link between hypertension and ARWMC, as well as the complex relationships between ARWMC and cognitive impairment, executive dysfunction, and movement/gait abnormalities. The available evidence supports the hypothesis that these functional consequences of ARWMC are responsible for substantial disability in the elderly. Thus, adequate treatment of hypertension may represent a feasible way to reduce the burden of disability in late life. (c) 2007 Elsevier B.V. All rights reserved.
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