Journal
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
Volume 462, Issue 2, Pages 210-219Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.abb.2007.02.006
Keywords
apoptosis; apoptosome; Atg genes; autophagy; starvation; survival; Beclin1
Categories
Funding
- Telethon [TCR04004] Funding Source: Medline
Ask authors/readers for more resources
Autophagy is a highly conserved catabolic programme for degrading proteins and organelles. This process has been shown to act as a pro-survival or pro-death mechanism in different physiological and pathological conditions. Several stress stimuli can induce autophagy, such as nutrient deprivation or critical steps in development of lower and higher eukaryotes. Apoptosis is an orchestrated form of cell death in which cells are actively involved in their own demise. Again, stress is a positive regulator of apoptosis and, in particular, of its apoptosome-mediated mitochondrial pathway. Besides discussing the individual roles played by the key molecules involved in autophagy in mammals in response to stress signals, we discuss here the interrelations between autophagy and apoptosis under these conditions. (C) 2007 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available