Journal
JOURNAL OF THE NEUROLOGICAL SCIENCES
Volume 257, Issue 1-2, Pages 250-254Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jns.2007.01.047
Keywords
tauopathies; tau phosphorylation; tau assembly; cognitive impairment
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The role of tau phosphorylation and tau aggregation in the pathology of a transgenic mouse model that overexpresses GSK-3 beta and FTDP-17 tau has been analyzed. In that model we have suggested a possible role for tau phospborylation, but not for tau aggregation, in the cognitive impairment found in the transgenic mouse. (c) 2007 Elsevier B.V. All rights reserved.
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