Journal
ANALYTICAL CHEMISTRY
Volume 86, Issue 5, Pages 2711-2718Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ac404104j
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Funding
- National Natural Science Foundation of China [21175023]
- Program for New Century Excellent Talents in University [NCET-12-0618]
- Natural Science Foundation of Fujian Province [2012J06019]
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A green approach is proposed for in situ growth of porous platinum nanoparticles on graphene oxide (PtNPs/GO). The resulting nanocomposite has been proven to function as peroxidase mimetics that can catalyze the reaction of peroxidase substrate in the presence of hydrogen peroxide. On the basis of the peroxidase-like activity, we used the PtNPs/GO as a signal transducer to develop a colorimetric assay for the direct detection of cancer cells. By using folic acid as a recognition element, a total of 125 cancer cells (MCF-7) can be distinguished by naked-eye observation. We envision that this nanomaterial could be used as a power tool for a wide range of potential applications in biotechnology and medicine.
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