Journal
ANALYTICAL CHEMISTRY
Volume 86, Issue 13, Pages 6192-6196Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ac5013859
Keywords
-
Categories
Funding
- RAS [5.1.1]
- RFBR [12-03-00403-a, 14-03-00374-a, 14-03-31239-mol-a]
- SB RAS [60, 61]
- program of support of leading scientific schools [NSh-2429.2012.3]
- Ministry of Education and Science of the Russian Federation
- Council on Grants of the President of the Russian Federation [MK-4391.2013.3]
- NIH ICMIC [5P50 CA128323-03, 5R00 CA134749-03, 3R00CA134749-02S1]
- DoD CDMRP Breast Cancer Program Era of Hope Award [W81XWH-12-1-0159/BC112431]
Ask authors/readers for more resources
Parahydrogen-induced polarization (PHIP) was used to demonstrate the concept that highly polarized, catalyst-free fluids can be obtained in a catalysis-free regime using a chemical reaction with molecular addition of parahydrogen to a water-soluble Rh(I) complex carrying a payload of compound with unsaturated (C=C) bonds. Hydrogenation of norbornadiene leads to formation of norbornene, which is eliminated from the Rh(I) complex and, therefore, leaves the aqueous phase and becomes a gaseous hyperpolarized molecule. The Rh(I) metal complex resides in the original liquid phase, while the product of hydrogen addition is found exclusively in the gaseous phase based on the affinity. Hyperpolarized norbornenec H-1 NMR signals observed in situ were enhanced by a factor of approximately 10 000 at a static field of 47.5 mT. High-resolution H-1 NMR at a field of 9.4 T was used for ex situ detection of hyperpolarized norbornene in the gaseous phase, where a signal enhancement factor of approximately 160 was observed. This concept of stoichiometric as opposed to purely catalytic use of PHIP-available complexes with an unsaturated payload precursor molecule can be extended to other contrast agents for both homogeneous and heterogeneous PHIP. The Rh(I) complex was employed in aqueous medium suitable for production of hyperpolarized contrast agents for biomedical use. Detection of PHIP hyperpolarized gas by low-field NMR is demonstrated here for the first time.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available