Journal
TOXICOLOGY AND APPLIED PHARMACOLOGY
Volume 221, Issue 3, Pages 384-394Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.taap.2007.03.006
Keywords
skin sensitization; dendritic cells; in vitro methods; hazard identification
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Recent advances have been made in our understanding of the roles played by cutaneous dendritic cells (DCs) in the induction of contact allergy. A number of associated changes in epidermal Langerhans cell phenotype and function required for effective skin sensitization are providing the foundations for the development of cellular assays (using DC and DC-like cells) for skin sensitization hazard identification. These alternative approaches to the identification and characterization of skin sensitizing chemicals were the focus of a Workshop entitled Dendritic Cells and Skin Sensitization: Biological Roles and Uses in Hazard Identification that was given at the annual Society of Toxicology meeting held March 6-9, 2006 in San Diego, California. This paper reports information that was presented during the Workshop. (c) 2007 Published by Elsevier Inc.
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