Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 16, Issue 2, Pages 3298-3306Publisher
MDPI
DOI: 10.3390/ijms16023298
Keywords
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Funding
- National Dong Hwa University
- National Museum of Marine Biology and Aquarium
- Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University
- Taiwan Kose Co. Ltd.
- Ministry of Science and Technology [NSC 103-2911-I-002-303, MOST 104-2911-I-002-302, MOST 103-2325-B-039-008, MOST 103-2325-B-039-007-CC1, MOST 103-2325-B-291-001, NSC 101-2320-B-291-001-MY3]
- National Health Research Institutes [NHRI-EX103-10241BI]
- Chinese Medicine Research Center, China Medical University (the Ministry of Education, the Aim for the Top University Plan), Taiwan
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A known norcembranoidal diterpene, 5-episinuleptolide (1), along with a new analogue, 4 alpha-hydroxy-5-episinuleptolide (2), were isolated from a cultured-type soft coral Sinularia numerosa. The structures of 1 and 2 were elucidated on the basis of spectroscopic methods and by comparison of the data with those of the related metabolites. Cytotoxicity of metabolites 1 and 2 against a panel of tumor cells is also described. Compound 2 exhibited moderate cytotoxicity toward CCRF-CEM cells with an IC50 value 4.21 mu g/mL. Preliminary SAR (structure activity relationship) information was obtained from these two compounds.
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