Copper-nanoparticle-catalyzed A3 coupling via C-H activation

Recyclable metal nanoparticles provide an efficient, economic, and novel route for the synthesis of propargylamines via three-component A(3) coupling reaction of aromatic aldehyde, amine and alkyne. This method provides a wide range of substrate applicability. This protocol avoids the use of heavy metal, co-catalyst and gives propargylamines in quantitative yield.