Journal
SYNLETT
Volume -, Issue 10, Pages 1581-1584Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2007-980365
Keywords
metal nanoparticles; propargylamines; heterogeneous catalysis; cyclic secondary amines; one-pot multicomponent reaction
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Recyclable metal nanoparticles provide an efficient, economic, and novel route for the synthesis of propargylamines via three-component A(3) coupling reaction of aromatic aldehyde, amine and alkyne. This method provides a wide range of substrate applicability. This protocol avoids the use of heavy metal, co-catalyst and gives propargylamines in quantitative yield.
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