Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 129, Issue 24, Pages 7484-+Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja070497d
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Funding
- Biotechnology and Biological Sciences Research Council [BB/C51444X/1, JF20607, JF20607/2] Funding Source: Medline
- NIGMS NIH HHS [GM074526, R21 GM074526, R01 GM065367] Funding Source: Medline
- Biotechnology and Biological Sciences Research Council [BB/C51444X/1, JF20607, JF20607/2] Funding Source: researchfish
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Herein we report on the single-molecule analysis of a conserved DNA quadruplex element found in the transcriptional activation site of the promoter of the proto- oncogene c-kit. We demonstrate that the c-kit quadruplex motif is able to fold into nonduplex states within a natural extended DNA duplex. There are apparent differences in putative quadruplex structures, and the K+ dependence on quadruplex formation, that appear to result when studying this quadruplex motif in natural duplex, as opposed to the single-stranded form.
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