Journal
ANALYTICAL CHEMISTRY
Volume 86, Issue 13, Pages 6508-6515Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ac5010103
Keywords
-
Categories
Funding
- NSFC [21135001, 21205143, 91127005, 21305036]
- Program for New Century Excellent Talents in University [NCET-13-0188]
- 973 National Key Basic Research Program [2011CB91100-0]
Ask authors/readers for more resources
Lanthanide-based upconversion nanoparticles (UCNPs) are a new type of luminescent tags that show great application potential in biomedical fields. However, a major challenge when applying UCNPs in biomedical research is the lack of a versatile strategy to make water-dispersible and biocompatible UCNPs with high simplicity in functionalization. To address this problem, in the present work, we employed 6-phosphate-6-deoxy-beta-cyclodextrin (beta PCD) as the novel ligand to fabricate a versatile upconversion luminescent nanoplatform. Using beta PCD as the surface ligand not only enhances the stability and biocompatibility of the UCNPs under physiological conditions but also enables simple conjugation with various functional molecules, such as organic dyes and biomolecules, via the host-guest interaction between those molecules and the cyclodextrin cavity. The conjugated upconversion nanoprobe then displays excellent capability in labeling the cancer cells and tumor tissue slices for luminescent imaging. These results demonstrate that the versatile cyclodextrin-functionalized upconversion nanoplatform appears particularly flexible for further modifications, indicating great potential for applications in biosensing and bioimaging.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available