Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 129, Issue 24, Pages 7498-+Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja072134j
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We report a new strategy for organocatalytic cascade reactions. Accordingly, enamine catalysis, iminium catalysis, and Bronsted acid catalysis can work in concert in a highly enantioselective organocatalytic cascade sequence toward chiral cis-3-substituted cyclohexylamines. We found that an achiral amine in combination with a catalytic amount of a chiral Bronsted acid can accomplish an aldol addition-dehydration-conjugate reduction-reductive amination to provide potential intermediates of pharmaceutically active compounds in good yields and excellent enantioselectivities.
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