Journal
ANALYTICAL CHEMISTRY
Volume 86, Issue 4, Pages 1932-1936Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ac403661z
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Funding
- National Basic Research Program of China (973 program) [2013CB932802, 2012CB932600]
- National Science Foundation of China [91127037, 91123037, 21373260]
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Molecular computing holds great promise for I diagnosis and treatment of diseases at the molecular level; nevertheless, designing molecular logic gates to operate programmably and autonomously for molecular diagnostics still remains challenging. We designed logic gates on DNA Origami for microRNA analysis. As a demonstration, two indicators of heart failure, microRNA-21 and microRNA-195, were selected as the logic inputs. The logic gates contain two main modules: computation module and output module, performing in a single DNA Origami nanostructure. The computation module recognizes disease indicators, while the output module display different nanoscale symbols, + (positive) or - (negative), depending on the computing results. We demonstrated that the molecular logic gates worked well with single and two input combinations.
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