Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 358, Issue 1, Pages 66-72Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2007.04.096
Keywords
IK3IP1; PI3K; p85; p110; kringle
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Funding
- NCI NIH HHS [R01 CA105242-02, R01 CA105242-01, R01 CA105242-04, R01 CA105242, R01-CA105242, R01 CA105242-03] Funding Source: Medline
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Signaling initiated by Class la phosphatidylinositol-3-kinases (PI3Ks) is essential for cell proliferation and survival. We discovered a novel protein we call PI3K interacting protein 1 (PIK3IP1) that shares homology with the p85 regulatory PI3K subunit. Using a variety of in vitro and cell based assays, we demonstrate that PIK3IP1 directly binds to the p110 catalytic subunit and down modulates PI3K activity. Our studies suggest that PIK3IP1 is a new type of PI3K regulator. (c) 2007 Elsevier Inc. All rights reserved.
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