Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 72, Issue 13, Pages 5016-5019Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo070533r
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Functionalized gamma-lactams are found to be crucial intermediates in the synthesis of biologically important natural products. We herein described a highly diastereoselective synthesis of beta-carboxy-gamma-lactams and their ethyl ester derivatives, in high yields with high diastereomeric ratio, via the Mukaiyama-aldol type reaction of 2,5-bis(trimethysilyloxy)furan with imines, employing Sc(OTf)(3) as a catalyst.
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