Journal
BEHAVIORAL AND BRAIN FUNCTIONS
Volume 3, Issue -, Pages -Publisher
BMC
DOI: 10.1186/1744-9081-3-30
Keywords
-
Categories
Funding
- NICHD NIH HHS [P01 HD031921] Funding Source: Medline
Ask authors/readers for more resources
Background: Antisocial behaviors are complex polygenic phenotypes that are due to a multifactorial arrangement of genetic polymorphisms. Little empirical research, however, has been undertaken that examines gene x gene interactions in the etiology of conduct disorder and antisocial behavior. This study examined whether adolescent conduct disorder and adult antisocial behavior were related to the dopamine D2 receptor polymorphism ( DRD2) and the dopamine D4 receptor polymorphism ( DRD4). Methods: A sample of 872 male participants from the National Longitudinal Study of Adolescent Health ( Add Health) completed self-report questionnaires that tapped adolescent conduct disorder and adult antisocial behavior. DNA was genotyped for DRD2 and DRD4. Results: Multivariate regression analysis revealed that neither DRD2 nor DRD4 had significant independent effects on conduct disorder or antisocial behavior. However, DRD2 interacted with DRD4 to predict variation in adolescent conduct disorder and in adult antisocial behavior. Conclusion: The results suggest that a gene x gene interaction between DRD2 and DRD4 is associated with the development of conduct disorder and adult antisocial behavior in males.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available