4.4 Article Proceedings Paper

Synthesis of migrastatin and its macrolide core

Journal

TETRAHEDRON
Volume 63, Issue 26, Pages 5918-5929

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2007.02.107

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Migrastatin and its macrolactone subunit are potent antimetastatic agents. Both were synthesized by using a ring-closing metathesis (RCM) to establish the macrolactone core, and the control of the (Z)-trisubstituted double bond at C11-C12 was achieved by using a Still-Gennari olefination. (C) 2007 Elsevier Ltd. All rights reserved.

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