Journal
FEBS LETTERS
Volume 581, Issue 16, Pages 2954-2958Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2007.05.050
Keywords
hepatic stellate cell; fibrosis; Wnt; secreted frizzled-related protein 1; apoptosis
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Wnt signaling was implicated in pulmonary and renal fibrosis. Since Wnt activity is enhanced in liver cirrhosis, Wnt signaling may also participate in hepatic fibrogenesis. Thus, we determined if Writ signaling modulates hepatic stellate cell (HSC) activation and survival. Wnt3A treatment significantly activated human HSCs, while this was inhibited in secreted frizzled-related protein 1 (sFRP1) overexpressing cells. Wnt3A treatment significantly suppressed TRAIL-induced apoptosis in control HSCs versus sFRP1 over-expressing cells. Particularly, caspase 3 was more activated in sFRP1 over-expressing cells following TRAIL and Wnt3A treatment. These observations imply that Wnt signaling promotes hepatic fibrosis by enhancing HSC activation and survival. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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