4.8 Article

Palladium-catalyzed direct functionalization of imidazolinone: Synthesis of dibromophakellstatin

Journal

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 129, Issue 25, Pages 7768-+

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ja072844p

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Funding

  1. NIGMS NIH HHS [R01 GM079554, R01 GM079554-01] Funding Source: Medline

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The direct C-H functionalization of imidazolinone is achieved with Pd(OAc)(2)/NaOAc in DMSO. Dibromophakellstatin can be synthesized in five steps with 40% overall yield using this new C-H activation method.

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