Journal
ANALYTICAL CHEMISTRY
Volume 85, Issue 20, Pages 9877-9881Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ac402409m
Keywords
-
Categories
Funding
- 973 Program [2013CB933800]
- National Natural Science Foundation of China [21227005, 21035003, 21205073]
- Specialized Research Fund for the Doctoral Program of Higher Education of China [20113704130001]
- Program for Changjiang Scholars and Innovative Research Team in University
- Science and Technology Development Programs of Shandong Province of China [2010G0020243]
Ask authors/readers for more resources
A newly synthesized reaction-based two-photon (TP) fluorescence imaging probe, 9-butyltriphenylphosphoniumacylamino-2,7-dibenzothiazolineflurene (MF-DBZH), composed of a superoxide anion (O-2(center dot-)) responsive group and a mitochondria-targeted site, has been shown to have high selectivity toward mitochondrial O-2(center dot-) fluxes. The fluorescence intensity of MF-DBZH responds proportionally to changes in O-2(center dot-) concentrations. Moreover, MF-DBZH was proved to be insensitive toward pH changes and has high photostability. Favorable features of this probe also include convenient cell loading, easy staining of both cells and small animals, and excellent biocompibility. Most importantly, MF-DBZH gives reliable TP fluorescent signal to changes of O-2(center dot-) levels in vivo.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available