Journal
TUBERCULOSIS
Volume 87, Issue 4, Pages 373-383Publisher
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.tube.2006.12.004
Keywords
V gamma 2V delta 2; gamma delta; repertoire; BCG; M. fascicularis; vaccine; animal model
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Funding
- NCI NIH HHS [R01 CA113261-03, R01 CA113261] Funding Source: Medline
- NIAID NIH HHS [T32 AI007540, R01 AI051212, AI51212, R21 AI051212] Funding Source: Medline
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The V gamma 2V delta 2 T cell subset responds to Bacille Calmette-Guerin (BCG) immunization in macaques and may be a component of protective immunity against tuberculosis. We characterized the effects of BCG on the V gamma 2V delta 2 T cell receptor repertoire by comparing the starting population of V gamma 2 chains in cynomolgus macaques with the repertoire found after priming or booster immunization with BCG. The starting repertoire was dominated by public V gamma 2 chain sequences that were found repeatedly among unrelated animals. Primary exposure to BCG triggered expansion of cells expressing public V gamma 2 chains and booster immunization was often associated with contraction of these same subsets. Thus, BCG-reactive V gamma 2 chains were present at high frequency in the repertoire of mycobacteria-naive macaques and they comprised the major response to primary or booster immunization. Normal selection processes that created the naive V gamma 2 repertoire in macaques, also encoded the capacity for rapid responses to mycobacteria. The unusual composition of a normal V gamma 2 repertoire helps to explain the powerful gamma delta T cell responses to BCG immunization. (c) 2007 Elsevier Ltd. All rights reserved.
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