Journal
CLINICAL PEDIATRICS
Volume 46, Issue 6, Pages 505-511Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0009922806298896
Keywords
Henoch-Schonlein purpura; glomerulonephritis; outcome; end-stage renal disease; hypertension
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This study investigated predictors of renal survival in children with Henoch-Schonlein purpura glomerulonephritis. Records of patients with Henoch-Schonlein purpura glomerulonephritis evaluated at our center, from 1953-1990, were reviewed. Data were abstracted from records of patients seen within 5 years. Others were mailed a questionnaire or contacted by telephone. Primary outcome measures were renal survival and presence of urinary abnormalities or hypertension. Of the 65 eligible patients with Henoch Schonlein purpura glomerulonephritis, follow-up data was obtainable for 81.5%. The median follow-up was 20 years. At last follow-up, 66% of patients had normal renal function and urinalyses, and 21% had progressed to end-stage renal disease. The only factor associated with the development of end-stage renal disease was the use of cytotoxic agents. There are no features at initial presentation that identify children at risk of disease progression. Close follow-up of all children with Henoch Schonlein purpura glomerulonephritis is warranted.
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