Journal
ANALYTICAL CHEMISTRY
Volume 85, Issue 15, Pages 7302-7307Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ac401198d
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Funding
- National Natural Science Foundation of China [21175135, 21205119]
- National Basic Research program of China (973 program) [2010CB933600]
- 100 Talents program of the Chinese Academy of Sciences
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Both Pb2+ and Ba2+ can bind with high affinity to some specific DNA sequences, inducing the formation of unimolecular G-quadruplex structures. Trans location of a DNA probe containing such sequences through an alpha-hemolysin nanopore in the presence of Pb2+ or Ba2+ . would result in much prolonged DNA translocation events. Quantification of these events can reveal the concentrations of Pb2+ or Ba2+ at as low as 0.8 nM. Besides, Pb2+ and Ba2+ in the solution can be simultaneously detected and individually identified. Furthermore, the probe is highly selective for Pb2+ and Ba2+ detection without interference from other metal ions. This sensing strategy can be extended to many other analytes which can bind to DNA molecules with high affinity.
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