Journal
BLOOD
Volume 110, Issue 1, Pages 9-17Publisher
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2006-12-022038
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Funding
- NCI NIH HHS [P0I CA111519, P01 CA111519, R01 CA079989, R01 R01 CA79989] Funding Source: Medline
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After allogeneic blood or bone marrow transplantation, donor T cells interact with a distorted antigen-presenting cell (APC) environment in which some, but not all, host APCs are replaced by APCS from the donor. Significantly, host APCs are required for the priming of acute graft-versus-host disease (GVHD). Donor APCs play a lesser role in the induction of acute GVHD despite their predicted capacity to cross-present host antigens. In contrast, donor APCs may play a role in perpetuating the tissue injury observed in chronic GVHD. Host APCs are also required for maximal graft-versus-leukemia responses. Recent studies have suggested potential strategies by which the continued presence of host APCs can be exploited to prime strong donor immunity to tumors without the induction of GVHD.
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