Journal
JOURNAL OF CLINICAL MICROBIOLOGY
Volume 45, Issue 7, Pages 2289-2292Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JCM.00349-07
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Funding
- NIAID NIH HHS [R01 AI051490, F31 AI052490, R01 AI051490-05, F31-AI52490, AI051490] Funding Source: Medline
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Vibrio cholerae strains from diverse O-antigen groups were evaluated for RTX toxin actin cross-linking activity. This study demonstrates that the actin cross-linking domain sequence is present within rtxA in the majority of clinical and environmental isolates tested, and the RTX toxin produced by these strains catalyzes the covalent cross-linking of cellular actin.
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