4.4 Article

Antigenic and genetic characterization of H9N2 swine influenza viruses in China

Journal

JOURNAL OF GENERAL VIROLOGY
Volume 88, Issue -, Pages 2035-2041

Publisher

MICROBIOLOGY SOC
DOI: 10.1099/vir.0.82783-0

Keywords

-

Ask authors/readers for more resources

As pigs are susceptible to infection with both avian and human influenza A viruses, they have been proposed to be an intermediate host for the generation of pandernic virus through reassortment. Antigenic and genetic characterization was performed for five swine H9N2 influenza viruses isolated from diseased pigs from different farms. The haemagglutinin (HA) antigenicity of swine H9N2 viruses was different from that of chicken H9N2 viruses prevalent in northern China. Genetic analysis revealed that all five isolates had an RLSR motif at the cleavage site of HA, which was different from those of A/duck/Hong Kong/Y280/97 (Dk/HK/Y280/97)-like viruses established in chickens in China. Phylogenetic analyses indicated that the five swine HgN2 viruses formed novel HA and neuraminidase sublineages that were related closely to those of earlier chicken H9 viruses and were also consistent with the extent of the observed antigenic variation. The six internal genes of the isolates possessed H5N 1-like sequences, indicating that they were reassortants of H9 and H5 viruses. The present results indicate that avian to porcine interspecies transmission of H9N2 viruses might have resulted in the generation of viruses with novel antigenic and genetic characteristics; therefore, surveillance of swine influenza should be given a high priority.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.4
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available