Journal
BONE
Volume 41, Issue 1, Pages 19-24Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.bone.2007.03.020
Keywords
primary hyperparathyroidisin; bone nucroarchitecture; histomorphometry
Categories
Funding
- NIAMS NIH HHS [AR051454, R01 AR051454] Funding Source: Medline
- NIDDK NIH HHS [R01 DK032333, R01 DK032333-24A2, DK32333] Funding Source: Medline
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By conventional 2-dimensional, histomorphometric analysis, we and others have previously shown that cancellous bone architecture is preserved in mild primary hyperparathyroidism (PHPT). We have now extended these observations to a 3-dimensional analysis using microcomputed tomography (microCT). Iliac crest bone biopsies were analyzed from the following subjects with PHPT: 22 postmenopausal women; 7 premenopausal women; similar numbers of normal pre-and postmenopausal women served as controls. Fifteen men with PHPT were also studied. Postmenopausal women with PHPT demonstrated features of preserved cancellous bone as shown by smaller age-related declines in cancellous bone Volume (BV/TV) and connectivity density (Conn.D) and no change in bone surface/total volume (BS/TV) as compared to normal women. In postmenopausal women with PHPT, cancellous bone volume (BV/TV), bone surface/total volume, and connectivity density (Conn.D)) were all higher, and trabecular separation (Tb.Sp) was lower than in postmenopausal controls. In sharp contrast to the findings in normal women, no structural variables in PHPT women were correlated with age. Also of note, there was no difference in any 3-dimensional index between women and men with PHPT. We conclude that three-dimensional, cancellous bone microarchitecture is preserved in patients with mild primary hyperparathyroidisrn. (C) 2007 Elsevier Inc. All rights reserved.
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