Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 349, Issue 10, Pages 1597-1603Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.200600495
Keywords
asymmetric catalysis; (S)-BINOL-titanium(IV) complex; Friedel-Crafts alkylations; 3-indolyl(hydroxy)acetates
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Enantioselective Friedel-Crafts alkylation reactions of a variety of indoles with ethyl glyoxylate, catalyzed by a chiral (S)-BINOL-Ti(IV) complex (10 mol%), are reported. The corresponding ethyl 3-indolyl(hydroxy)acetates were formed in good yields and with high enantiomeric excess (up to 96%). When methyl pyruvate or p-chlorophenylglyoxal was used, the bisindole compound was obtained in excellent yield. A possible mechanism is proposed.
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