4.5 Review

Ultrasound Elastography and MR Elastography for Assessing Liver Fibrosis: Part 2, Diagnostic Performance, Confounders, and Future Directions

Journal

AMERICAN JOURNAL OF ROENTGENOLOGY
Volume 205, Issue 1, Pages 33-40

Publisher

AMER ROENTGEN RAY SOC
DOI: 10.2214/AJR.15.14553

Keywords

elasticity; elastography; liver fibrosis; MR elastography (MRE); MRI; ultrasound; viscosity

Funding

  1. Canadian Institutes of Health Research - Institute of Nutrition, Metabolism, and Diabetes (CIHR-IMND) [273738, 301520]
  2. Centre de Recherche du Centre Hospitalier de l'Universite de Montreal (CRCHUM)
  3. Fonds de recherche du Quebec en Sante and Association des Radiologistes du Quebec (FRQS-ARQ) [26993]
  4. Canadian Institutes of Health Research [MOP-84358, CPG-95288]
  5. Natural Sciences and Engineering Research Council of Canada [CHRP-365656-09]
  6. Fonds Quebecois de la Recherche sur la Nature et les Technologies [FQRNT PR-174387]
  7. National Institute of Diabetes and Digestive and Kidney Diseases [R56DK090350, R01DK088925]

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OBJECTIVE. The purpose of the article is to review the diagnostic performance of ultrasound and MR elastography techniques for detection and staging of liver fibrosis, the main current clinical applications of elastography in the abdomen. CONCLUSION. Technical and instrument-related factors and biologic and patient-related factors may constitute potential confounders of stiffness measurements for assessment of liver fibrosis. Future developments may expand the scope of elastography for monitoring liver fibrosis and predict complications of chronic liver disease.

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