Journal
ANALYTICAL CHEMISTRY
Volume 85, Issue 1, Pages 208-212Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ac302510g
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Funding
- National Institutes of Health [R01 EB006201, R01 ES014774, T32 EB001040]
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB006201, T32EB001040] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [R01ES014774] Funding Source: NIH RePORTER
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Surface-enhanced Raman scattering (SERS)-active plasmonic nanomaterials have become a promising agent for molecular imaging and multiplex detection. To produce strong SERS intensity while retaining the non-aggregated state and biocompatibility needed for bioapplications, we integrated near-infrared (NW) responsive plasmonic gold nanostars with resonant dyes for resonant SERS (SERRS). The SERRS on nanostars was several orders of magnitude greater than signals from SERRS on nanospheres and nonresonant SERS on nanostars. For the first time, we demonstrated quantitative multiplex detection using four unique nanostar SERRS probes in both in vitro solutions and ex vivo tissue samples under NIR excitation. With further optimization, in vivo tracking of multiple SERRS probes is possible.
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