Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 187, Issue 1-2, Pages 179-186Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2007.04.016
Keywords
CD163; multiple sclerosis; metal loprotemase; monocytes; sCD 1 63; scavenger receptor
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The scavenger receptor CD 163 is selectively expressed on tissue macrophages and human monocytes. CD 163 has been implicated to play a role in the clearance of hemoglobin and in the regulation of cytokine production by macrophages. Membrane CD163 can be cleaved by rnatrix metal loproteinases (MMP) resulting in soluble CD163 (sCD163). In the present report the shedding of CD163 was investigated in multiple sclerosis (MS). An upregulation of plasma sCD 163 and a down regulation of membrane CD 163 in MS patients compared to healthy controls was observed. The levels of plasma sCD163 correlated with plasma MMP-9 levels in controls, but not in MS patients. Moreover, evidence was obtained for CD163-cleaving MMP activity in plasma of MS patients. Finally, the increased proteolytic shedding of CD163 correlated to reduced plasma levels of circulating inflammatory cytokines. Collectively, our results provide evidence for proteolytic shedding of CD163 in MS and suggest a possible link to cytokine production. (c) 2007 Elsevier B.V. All rights reserved.
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