Journal
BIOLOGICAL CHEMISTRY
Volume 388, Issue 7, Pages 665-678Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1515/BC.2007.090
Keywords
catalytic RNA; protein-assisted splicing; ribozyme
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Group II introns are large autocatalytic RNAs found in organellar genomes of plants and lower eukaryotes, as well as in some bacterial genomes. Interestingly, these ribozymes share characteristic traits with both spliceosomal introns and non-LTR retrotransposons and may have a common evolutionary ancestor. Furthermore, group II intron features such as structure, folding and catalytic mechanism differ considerably from those of other large ribozymes, making group II introns an attractive model system to gain novel insights into RNA biology and biochemistry. This review explores recent advances in the structural and mechanistic characterization of group II intron architecture and self-splicing.
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