Journal
ANALYTICAL CHEMISTRY
Volume 84, Issue 8, Pages 3696-3702Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ac300204z
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Funding
- U.S. National Science Foundation [CHE-0809795]
- National Institute of Health [5R01EB011591]
- Excellence Initiative of the German Federal and State Governments
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Inductively coupled planar resonators offer convenient integration of high-resolution NMR spectroscopy with microfluidic lab-on-a-chip devices. Planar spiral resonators are fabricated lithographically either by gold electroplating or by etching Cu laminated with polyimide. Their performance is characterized by NMR imaging as well as spectroscopy. A single-scan limit of detection LODt = 0.95 nmol S-1/2 was obtained from sample volumes around 1 mu L. The sensitivity of this approach is similar to that obtained by microstripline and microslot probes.
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